@INRAE Delphine Rousseau-Ralliard Légende : A summary of the feto-placental effects of maternal exposition to a high-gat diet either during preconceptional or gestational periods

BREED publication in Front Physiol. Rousseau-Ralliard & al.

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BREED publication in Front Physiol. Rousseau-Ralliard & al.

High-fat maternal diet affects offspring phenotype: importance of windows of exposure

Being overweight or obese, in association with a high-fat diet is a major problem for public health, especially in women of childbearing age. We showed that in the rabbit, a high-fat maternal diet (H) administered at puberty and during gestation, affects the embryo development at the blastocyst stage, inducing intra-uterine growth retardation and placental metabolic sex-specific adaptations, without allowing to discriminate the effect of preconceptual exposition from that of gestational exposition.

In order to identify a window of vulnerability associated to a H diet, embryo cross-transfers of H rabbits or control (C) rabbits were performed in C or H receivers on the first day of gestation. Even though HC was not identical to the CC group, phenotypic differences that persisted between these two groups, at the end of gestation, were negligeable, not excluding repercussions on progeny health at adult age. However, the HH group presented a different phenotypic profile in terms of fetal growth and placental and hepatic lipid contect as compared to the CH group. These results suggest that when maternal obesity occurs due to diet, an intervention in early gestation, limiting fat intake, could partially correct the offspring's phenotype.

Contacts : INRAE-UMR1198 BREED- Equipe PEPPS

  • Delphine Rousseau-Ralliard (delphine.rousseau@ inrae.fr)
  • Anne Couturier-Tarrade (anne.couturier-tarrade@inrae.fr)

See also

Reference:

Importance of Windows of Exposure to Maternal High-Fat Diet and Feto-Placental Effects: Discrimination Between Pre-conception and Gestational Periods in a Rabbit Model.
Rousseau-Ralliard D, Aubrière MC, Daniel N, Dahirel M, Morin G, Prézelin A, Bertrand J, Rey C, Chavatte-Palmer P, Couturier-Tarrade A. Front Physiol. 2021 Nov 25;12:784268. doi: 10.3389/fphys.2021.784268. eCollection 2021

For more information:

Sexual dimorphism of the feto-placental phenotype in response to a high fat and control maternal diets in a rabbit model. Tarrade A, Rousseau-Ralliard D, Aubrière MC, Peynot N, Dahirel M, Bertrand-Michel J, Aguirre-Lavin T, Morel O, Beaujean N, Duranthon V, Chavatte-Palmer P. PLoS One. 2013 Dec 26;8(12):e83458. doi: 10.1371/journal.pone.0083458.

Modification date : 14 September 2023 | Publication date : 05 April 2022 | Redactor : UMR BREED - Edition P. Huan - Translation W. Brand-Williams