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INRAE

24, chemin de Borde Rouge -Auzeville - CS52627 31326 Castanet Tolosan cedex - France

Last update: May 2021

News

INRAE, Auteur Nicolas Bertrand (bassin de truites en pisciculture)

Article

02 November 2023

Redaction: Edition P. Huan

Phenotyping isogenic trout lines to elucidate mechanisms of resistance to bacterial infection

In a study published in Microbes & Infection, researchers from the Infection et Immunité des Poissons team (Virologie et Immunologie Moléculaires - VIM unit, INRAE/UVSQ/UPSaclay, Jouy-en-Josas), in collaboration with INRAE's GABI and IERP units, have established a set of phenotypes linked to pathogenesis through the characterization of a collection of isogenic trout lines with contrasting resistance. Guided by the 3Rs principle, individual monitoring by non-lethal blood sampling has been applied for the first time in trout to monitor bacterial infection and host response; this approach makes it possible both to reduce the number of fish used and to increase the power of the experimental set-up.

@ Alicia Jacques

Article

02 November 2023

Redaction: A. Jacques - G. Restoux - Edition P. Huan

Reintroduction of genetic diversity in populations from frozen semen: The case of Abondance, a local French dairy cattle breed

Genetic diversity is the genetic variability between individuals in the same population or between populations. In the case of livestock, breeds are often equated with populations, and the diversity they contain is essential for their evolution and adaptation. However, breeding is about selecting the best individuals and therefore does not maintain the full diversity of animals. However, it is possible to freeze semen from bulls to preserve it and potentially use it later.

Article

14 September 2023

Redaction: INRAE - Edition P. Huan

Thesis offer "Hologenomic methods to account for host microbiota in genetic evaluations"

This project will contribute to establishing clear guidelines for the simulation of realistic hologenomic data, the construction of microbiota-based similarity matrices, and the optimal combination of genomic, microbiota, and multi-omics data in a wide variety of scenarios.

Article

14 September 2023

Redaction: SAPS - Edition P. Huan

Thesis project "Genetic and epigenetic spatial population structure of local chicken breeds."

Funded by the European project H2020 GERONIMO, the thesis project proposes to study the genetic and spatial epigenetic structure of at least 16 local European chicken breeds and their determinants.

@ INRAE Photothèque, Atueur Gilles Vasseur Delaitre

Article

14 September 2023

Redaction: SAPS - Edition P. Huan

Thesis offering "Genetic determinism of vaccine response and caecal microbiota composition in free-range chickens."

This thesis will contribute to the production of knowledge that will make it possible to support the change of practices, in particular in terms of integrated management of health and well-being in free-range poultry farms.

@ Alejandro Cabezas-Cruz

Article

02 November 2023

Redaction: SAPS - Edition P. Huan

Avian Malaria Modulate Gut Microbiome in Canaries

Parasites are known to influence various aspects of their host biology. Recent evidence shows that host microbiome modulation by infection is one of the strategies of vector-borne parasites to affect host immunity and physiology. Although avian malaria is a common disease affecting wild birds, very little information is available about its impact on the gut microbiome of wild birds. This is the first study testing wild bird gut microbiome modulation after experimental infection with avian malaria parasite.

Article

02 November 2023

Redaction: SAPS - BIPAR - Edition P. Huan - Translation W. Brand-Williams

Apolline Maitre will participate in the finals of the Paris-Est Sup international contest « My thesis in 180 seconds».

The finals of the Paris-Est Sup international contest "My thesis in 180 seconds" will be held on March 14 at 15:30 at the University Gustave Eiffel, Marne-la-Vallée campus. Organized by the CNRS and France Universities, "My thesis in 180 seconds" is the French adaptation of the Australian contest "Three Minute Thesis" in which candidates must summarize their thesis subject with only one slide and in three minutes only, while ensuring that they be concise, convincing, and understandable by the all the audience.

INRAE

Article

14 September 2023

Redaction: INRAE - Edition P. Huan - translation W. Brand-Williams

INRAE 2023 Research Scientist Compteitions: discover the Junior Research Scientist Postions available in SAPS units!

Would you like to contribute to public researh, to be involved in future projects that answer society's challenges? Then join one of our research teams by enrolling in the Junior Research Scientist competitions: submission deadline through March 2, 2023.

Sciences Animales Paris-Saclay

Article

14 September 2023

Redaction: UMR BIPAR-UZB - Edition P. Huan - Translation W. Brand-Williams

A systematic review and prevalence modeling of Toxoplasma gondii as a function of age in cattle, ild animals and felines in Europe

A sytematic review of the litterature was done by a team of 20 scientists from 13 European countries using the on-line free tool, Cadima, containing 226 available publications. This systematic review was followed up with a meta-analysis using a Bayesian model including relevant covariables in order to create an age-dependent model for T. gondii prevalence in over 50 animal species. The results of this meta-analysis can be used to extrapolate data from regions where data are missing and to provide precious information for future approaches aimed at estimating the relative contribution of different sources of human infection by T. gondii.

@K. Adjou

Article

02 November 2023

Redaction: SAPS Rédaction K. Adjou - Edition P. Huan

Academic meeting on December 1st, 2022 "Emerging zoonoses"

As part of the French Veterinary Academy, we organized a seminar on "emerging zoonoses" at the EnvA. This half-day of presentations and discussions gave participants the chance to discover several emerging bacterial and parasite diseases, transmissible to man and associated with environmental problematics.

@ INRAE

Article

02 November 2023

Redaction: INRAE - Edition P. Huan - Translation W. Brand-Williams

Rustic breeds seminar

Scientists and animal population managers will exchange their views on the concepts of "Rusticity, robustness, resilience, adapations" during the presentations and round-table discussions of this seminar.

INRAE

Article

02 November 2023

Redaction: F. Phocas GABI - Cellule communication SAPS P. Huan

Genome-wide association study and genomic prediction of tolerance to acute hypoxia in rainbow trout.

Fish are exposed to large variations in the concentration of oxygen in their aquatic environment. When oxygen is depleted in relation to what is needed to maintain the energy metabolism of fish, this is called hypoxia. Hypoxia is one of the major threats to the aquaculture sector, causing substantial economic losses for fish farmers. It can strongly affect the health and welfare of fish, impacting on growth, reproduction, behaviour, immunity and other energy-demanding activities. Thus, improving hypoxia tolerance is of great economic and ethical interest to be included in aquaculture breeding programmes.

INRAE. Marie-Christine Lhopital, Race bovine limousine au coeur des Monts du Lyonnais (Sourcieux les Mines, Rhone)

Article

02 November 2023

Redaction: GABI - Cellule communication SAPS - P. Huan

The MYH3 gene, coding for an embryonic myosin, is mutated in a recessive form of cleft palate in Limousin cattle

Among the anomalies reported to the Observatoire National des Anomalies Bovines (ONAB, www.onab.fr), a form of cleft palate emerged in 2012 in Limousin cattle. The animals have a total cleft palate involving the bony palate and the muscular palate. In the majority of cases, no other clinical signs are associated with cleft palate. Nevertheless, the survival of the animals and their well-being are largely compromised by this anomaly.

CC Pikist

Article

02 November 2023

Redaction: GABI - Edition P. Huan

A promising therapeutic strategy for COVID-19: antisense oligonucleotide technology.

The current COVID-19 pandemic continues to require new and effective therapeutic strategies. We explored antisense therapy using oligonucleotides targeting the genome of the severe acute respiratory syndrome coronavirus (SARS-CoV-2). We are pleased to announce the publication of this GABI-VIM-Univ Andres Bello (Santiago, Chile) collaborative work on the experimental demonstration of the activity of Antisense Oligonucleotides to inhibit in vitro the replication of SARS-CoV-2 virus, responsible for COVID-19.

Article

14 September 2023

Redaction: SAPS- Edition P. Huan - Tranlation W. Brand-Williams

The Animal Health Laboratory in Maison Alfort (UMR1161 Virologie) is recruting a Scientific and Technical Project Manager in Virology (M/W)

You will participate in the development of new research themes at the interface between virology, immunology and parasitology and/or microbiology.

@INRAE Bertrand Nicolas

Article

14 September 2023

Redaction: INRAE - Edition P. Huan

Genetics for sustainable aquaculture: a review of 20 years of rainbow trout breeding

While fishing has reached its limits, the demand for fish is increasing every year. In this context, aquaculture constitutes an alternative, provided that it is sustainable while allowing a quality production. INRAE, the Aqualande group and its trout selection and reproduction company "les Sources de l'Avance", and the Syndicat des Sélectionneurs Avicoles et Aquacoles Français (SYSAAF) have carried out a review of a 20-year rainbow trout selection program conducted by the company. They compared the growth and feed requirements of trout from this program with those of non-selected trout. Their results, published in Aquaculture Reports, show that 17 to 20 percent less feed is now required for the same growth of the fish with the selected trout, thus reducing the environmental impact. A locally produced sustainable feed, without fish oil, fish meal or soy, was also tested on both groups of fish. Growth gains and nutritional qualities are maintained with this feed of the future. This original work on a global scale shows that genetic improvement and innovative feed development can be effectively combined to contribute to a more sustainable aquaculture.

INRAE @ N. Beaujean

Article

02 November 2023

Redaction: V. Duranthon, BREED - Edition P. Huan

Major transcriptomic, epigenetic and metabolic changes underlie the pluripotency continuum in the rabbit

Since 2008, researchers from the Biology of Reproduction, Environment, Epigenetics and Development Unit (UMR1198 BREED) have been collaborating with the INSEM unit (U1208,INRAE USC1361 Stem Cell and Brain Research Institute) to characterize pluripotency in the rabbit embryo and to derive naive pluripotent stem cells (ESC or iPSC) in this species. This long-term collaboration has already resulted in several publications and has just reached a new stage with the publication of an article in Development.

INRAE @ C. Robert

Article

02 November 2023

Redaction: INRAE Service presse - Edition P. Huan

Endurance: the horse's microbiota enters the race

The science of microbiota is not limited to humans. It applies to many animals, including endurance horses. Although their microbiota influences their athletic abilities, its genetic composition and variability are not known. This is why researchers from INRAE, in collaboration with the Ecole Nationale Vétérinaire d'Alfort (EnvA), have compiled an exhaustive catalog of the genes of the gut microbiota in endurance horses. These innovative results, published on October 3 in the journal Nature Communication, provide valuable knowledge for advancing towards personalized animal nutrition.

@B. Nicolas INRAE

Article

02 November 2023

Redaction: INRAE - Edition P. Huan

A new biotechnology effective in blocking the multiplication of SARS-CoV-2

More than 600 million people have been infected with SARS-CoV-2 since 2020. Vaccines limit severe forms of the disease but do not block the spread of the virus. Several strategies are therefore being developed in parallel, including blocking the multiplication of the virus in the nose. This is what scientists from the VIM unit (UMR INRAE-UVSQ), in collaboration with EnvA and the University of Paris-Saclay, have succeeded in doing. They have selected and used proteins that prevent the virus from attaching and limit its multiplication. These promising results were published on September 6 in the journal PLOS Pathogens.

Article

02 November 2023

Redaction: GABI - E. Barrey - Edition P. Huan

A special issue of Frontiers Research topics on the role of non-coding RNAs involved in communication between the nuclear and mitochondrial genomes

An international working group on the role of non-coding RNAs involved in communication between the nuclear and mitochondrial genomes has just published a special issue on this topic . This research theme aims to gather knowledge on the role of non-coding RNAs (ncRNAs) involved in the communication pathways between mitochondria and the cell. This special issue of Frontiers in Physiology presents unique research focused on mitochondria-associated ncRNAs as well as original papers demonstrating the therapeutic potential of certain RNAs. Researchers from the SAPS GABI unit (BIGE team) are actively involved in the scientific work in this field.

@INRAE M. Dupont-Nivet

Article

02 November 2023

Redaction: GABI - Edition P. Huan

A powerful new tool for identifying genes of interest in farmed fish: a high-density chip with 665,000 genetic markers for rainbow trout

The knowledge of the variations of the DNA sequence which constitutes the genome of an individual is a central information in genetic research. If it is possible to sequence the entire genome to know all these variations, it remains very expensive. Genotyping chips, which are much less expensive, make it possible to work with an intermediate density of information (corresponding to a selection of positions, or "markers", judiciously distributed over the genome). However, their efficiency is directly related to the number of available markers. For rainbow trout, the leading farmed fish species in France, INRAE and its partners have just developed a new high-density genotyping chip (665,000 markers, i.e. about 15 times more than the best tools available so far), which greatly increases the analysis power obtained. By providing access to much more precise genomic information, this chip will make it easier to identify the genes responsible for differences between individuals and to develop more effective selection procedures to adapt animals to changing environmental conditions.

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